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Cirrhosis and related Liver Diseases

Disease of the liver caused by chronic damage to its cells. Internal scarring of liver tissue damaging the normal structure of the liver. The liver is unable to remove toxins from the blood. Alcohol is normally the cause of Cirrhosis of the liver. Hepatitis (inflammation of the liver) can lead to cirrhosis.

Some characteristics changes on Body Composition in Cancer patients

Weight loss
Loss appetite
Loss of Body Call Mass (BCM)
Change in Body Composition


Monitoring Body Composition

Body composition changes decreasing Body Fat and BCM with severity of cirrhosis. Depletion of BCM can go un-notice due to abnormal fluid retention (i.e., ascites), which is common in cirrhosis patients. In this group the TBW/FFM was found to increase with the severity of disease, while the protein decreased. Not only is Body fat lower, this group was found to have less Body Cell Mass and Body Mineral Density.

Maltron Analysers a screening tool for measurements of clinical evaluation of patients with liver diseases.

TECHNICAL PAPERS

Bramley P, Oldroyd B, Stewart S, Simpson M, Truscott J, Losowsky M, Smith H. Body composition analysis in liver cirrhosis. The measurement of body fat by dual energy X-ray absorptiometry in comparison to skinfold anthropometry, bioelectrical impedance and total body potassium. Basic Life Sci 1993:60:211-4.

De Leon R, Cabre E, Esteve PM, Morillas R, Quer JC, Planas R, Bertran X, Domenech E, Guilera M, et al. Value of body impedance analysis (BIA) in assessing body composition BC in cirrhosis with ascites [abstract]. J Hepatol 1991;13 Suppl 2:S114.

Guglielmi FW, Mastronuzzi T, De Marco F, Laddaga U, Balestrazzi A, Panella C, Francavilla A. [Correlation between bioelectric parameters and anthropometry in patients with chronic liver disease]. Riv Ital Nutr Parenter Enteral 1991;9(2):97-1O2. (Ita).

Guglielmi W G, Contento F, Laddaga L. Bioelectric Impedance Analysis: Experience with Male Patients with Cirrhosis. Hepatol. 1991: 13(5): 892-895

Lautz H U, Selbeng O, Korber J, Burger M, Huller M J. Protein-calorie malnutrition in liver cirrhosis. Clin-Investig. 1992; Jun, 70(6): 478-86

Madden A M, Morgan M Y. A comparison of skinfold anthropometry and bioelectrical impedance analysis for measuring percentage body fat in patients with cirrhosis. Journal of Hepatology, N 21: 878-883

Muller M J, Lautz H L, Plogmann B, Burger M, Korber J, Schmidt F W impact of cause, clinical staging and nutritional state. Hepatology. 1992 1 Energy expenditure and substrate oxidation in patients with Cirrhosis: The; 15: 782 - 794

Muller M J, Pirlich M, Balks H J, Selbeng O. Glucose intolerance in liver cirrhosis: Role of hepatic and non-hepatic influences - European Journal of Clinical Chemistry and Clinical Biochemistry - 1994; 32 , N 10 749- 758

Panella C, Guglielmi FW, Francavilla A. Nutritional status in cirrhosis: role of Bioelectric impedance analysis. Ital J Gastroenterol 1993 Aug-Sep;25(7) :402-7.

Zillikens, M.C., van den Berg, J.W., Wilson, J.H., Rietveld, T., & Swami, G.R. (1992). The validity of bioelectrical impedance analysis in estimating body water in patients with cirrhosis. Journal of Hepatology, 16, 59-65.